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Patricia Anne Wettig (born December 4, 1951) is an American actress and playwright. She is best known for her role as Nancy Weston in the television series Thirtysomething (1987–1991), for which she received a Golden Globe Award and three Primetime Emmy Awards. After her breakthrough role in Thirtysomething, Wettig has appeared in a number of films, include Guilty by Suspicion (1991), City Slickers (1991), City Slickers II: The Legend of Curly's Gold (1994), and The Langoliers (1995). She returned to television playing a leading role in the 1995 short-lived drama Courthouse and later played Caroline Reynolds in the Fox drama Prison Break (2005–2007) and Holly Harper in the ABC family drama Brothers & Sisters (2006–2011).

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