Mercedes Brignone (18 May 1885 – 24 June 1967) was a Spanish-born Italian stage, film and television actress. She was the daughter of the actor Giuseppe Brignone. She often played divas, and appeared in numerous silent films for Milano Films during the 1910s. In later years she played largely supporting roles. She was the older sister of film director and actor Guido Brignone and the aunt of actress Lilla Brignone.